• U.S. Brand Names: Sprix®
• Pharmacologic Category: Nonsteroidal Anti-inflammatory Drug (NSAID), Nasal

• It is used to ease pain.
• Ketorolac tromethamine blocks chemicals that cause pain and swelling.

How to take

• Do not take this drug by mouth. For the nose only. Keep out of mouth and eyes (may burn).
• Blow your nose before use.
• Read and follow how to use facts given with spray. Using the spray the right way is very major.
• Use a new spray bottle each day and throw away old spray used the day before.

Missed Dose

• Take a missed dose as soon as you think about it.
• If it is close to time for the next dose, skip the missed dose and return to your normal time.
• Do not take two doses or extra doses.
• Many times this drug is used on an as needed basis.

Storage

• Store unopened containers in a refrigerator. Do not freeze.
• Store opened nose spray bottle at room temperature. Throw away any unused drug after 24 hours.
• Protect from light.

Warnings

• This drug may raise the chance of heart attack, stroke, and high blood pressure. This has been observed with long-term use or at critical times (right after heart surgery). Use care if you have risk factors for heart disease (high blood pressure, high cholesterol, overweight, high blood sugar (diabetes), cigarette smoking, man older than 40 years of age, other family members with early heart disease, postmenopausal woman).
• Do not use this drug right before or after heart bypass surgery.
• This drug may raise the chance of ulcers or bleeding from the stomach or bowel. Talk with doctor.
• This drug is only to be used for 5 days total. It is for very bad, short-term pain. It may cause not safe side effects if taken more than 5 days. Let doctor know if you have ulcer disease, kidney disease, a chance of bleeding or any active bleeding, allergies to ketorolac, aspirin, or any other pain drugs. Do not take if you are pregnant or breast-feeding. Tell doctor if you are 65 years of age or older or weigh less than 110 pounds.
• Unsafe reactions may happen. This drug cannot be taken while you are taking certain other drugs. Check all the drugs you are taking with your doctor.
• Please read the medication guide.

Avoid

• If you have an allergy to ketorolac tromethamine or any other part of this drug.
• If you have an allergy to EDTA.
• Tell doctor if you are allergic to any drugs. Make sure to tell about the allergy and what signs you had. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs involved.
• If you have any of these health problems: Bleeding in the brain, bleeding problems, hole in the GI (gastrointestinal) tract, recent GI bleeding, very bad kidney disease, ulcer disease, or use before major surgery.
• If you are more than 30 weeks pregnant.
• If you are breast-feeding.

Precautions

• Do not use this drug for more than 5 days.
• If you are 65 or older or weigh less than 110 pound, you may need a smaller dose. You could have more side effects.
• If you have asthma, talk with doctor.
• If you have high blood pressure, talk with doctor.
• If you have kidney disease, talk with doctor.
• If you have liver disease, talk with doctor.
• If you have a weak heart, talk with doctor.
• Check drugs with doctor. This drug may not mix well with other drugs.
• Talk with doctor before using other aspirin, products that have aspirin, blood thinners, garlic, ginseng, ginkgo, ibuprofen or like products, pain drugs, or vitamin E.
• Tell dentists, surgeons, and other doctors that you use this drug.
• You may bleed more easily. Be careful and avoid injury. Use a soft toothbrush and an electric razor.
• Avoid alcohol (includes wine, beer, and liquor).
• Tell doctor if you are pregnant or plan on getting pregnant.

Side Effects

• Nose pain or irritation.
• Tearing.
• Belly pain.
• Loose stools.

Monitoring

• Change in health problem being treated. Is it better, worse, or about the same?
• Follow up with doctor.

Contact a healthcare provider

• If you suspect an overdose, call your local poison control center or ER right away.
• Signs of a very bad reaction to the drug. These include wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat.
• Chest pain or pressure.
• Change in strength on one side greater than the other, trouble speaking or thinking, change in balance, or blurred eyesight.
• Very upset stomach or throwing up.
• Very bad belly pain.
• Very bad swelling or pain of hands or feet.
• Major weight gain.
• Black, tarry, or bloody stools.
• Blood in the urine.
• Very bad loose stools.
• Unusual bruising or bleeding.
• Any rash.
• Health problem is not better or you are feeling worse.

General Statements

• If you have a very bad allergy, wear allergy ID at all times.
• Do not share your drugs with others and do not take anyone else's drugs.
• Keep all drugs out of the reach of children and pets.
• Most drugs can be thrown away in household trash after mixing with coffee grounds or kitty litter and sealing in a plastic bag.
• In Canada return any unused drugs back to the pharmacy. Also, visit http://www.hc-sc.gc.ca/hl-vs/iyh-vsv/med/disposal-defaire-eng.php#th for more facts about the right way to get rid of unused drugs.
• Keep a list of all your drugs (prescription, natural products, supplements, vitamins, OTC) with you. Give this list to your doctor.
• Call your doctor for health help about side effects. You may also call the FDA at 1-800-FDA-1088 or in Canada to Health Canada's Canada Vigilance Program at 1-866-234-2345.
• Talk with doctor before starting any new drug, including OTC, natural products, or vitamins.

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